Table of Contents > Drug > Linezolid Print

Linezolid

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Notes
Related terms
Uses
Dosing
Safety
Author information

Notes

    Related terms
    • Brand Names: U.S.: Zyvox®
    • Brand Names: Canada: Zyvoxam®
    • Mexican Brand Names: Zyvoxam
    • Pharmacologic Category: Antibiotic, Oxazolidinone

    Uses
    • It is used to treat bacterial infections.
    • Linezolid works to harm the bacteria and fight the infection.

    Dosing

    How to take

    • To gain the most benefit, do not miss doses.
    • Use as you have been told, even if you are feeling better.
    • Take with or without food. Take with food if it causes an upset stomach.
    • Follow a diet plan. Some foods and drinks taken with this drug may cause very risky effects such as sudden high blood pressure. To avoid these problems, get a list of foods to avoid.
    • Avoid eating aged cheeses and meats, soy sauce, soy bean including paste, Miso soup, Italian green beans (fava beans), snowpea or broad bean pods, sauerkraut, kimchee, yeast extracts (Marmite), red or white wine, and beer including alcohol-free beer.
    • If this drug is stopped, follow diet for at least 2 more weeks.
    • There is a liquid (suspension) if you cannot swallow pills. Gently mix before use. Do not shake.
    • Those who have feeding tubes may also use the liquid. Flush the feeding tube before and after this drug is given.
    • Shot:
    • It is given as a shot into a vein over a period of time.

    Missed Dose

    • Take a missed dose as soon as you think about it.
    • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
    • Do not take 2 doses at the same time or extra doses.

    Storage

    • Store at room temperature.
    • Protect from light.
    • Protect tablets from water. Do not store in a bathroom or kitchen.
    • Store liquid (suspension) at room temperature. Throw away any part not used after 3 weeks.
    • Follow how to store the shot closely. Talk with the doctor.

    Safety



    Warnings

    • Linezolid may cause anemia, low white blood cell counts, low platelet counts, or may lower all cells made in the bone marrow. Blood tests will be done each week while on this drug.
    • Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.

    Avoid

    • If you have an allergy to linezolid or any other part of this drug.
    • Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have very high blood pressure.
    • If you have taken isocarboxazid, phenelzine, or tranylcypromine in the last 14 days. Monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine) must be stopped 14 days before this drug is started. Taking both at the same time could cause risky high blood pressure.
    • If you are taking any of these drugs: Citalopram, fluvoxamine, paroxetine, or sertraline. Do not use within 2 weeks of other antidepressants.
    • Stop fluoxetine for at least 5 weeks before starting this drug.

    Precautions

    • If you have high blood pressure, talk with your doctor.
    • Have your blood pressure and heart rate checked often if you have heart disease.
    • If you have an overactive thyroid, talk with your doctor.
    • If you have PKU, talk with your doctor. Some products have phenylalanine.
    • If you have seizures, talk with your doctor.
    • Have your blood work checked often. Talk with your doctor.
    • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
    • If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
    • Tell your doctor if you are pregnant or plan on getting pregnant.
    • Tell your doctor if you are breast-feeding.

    Side Effects

    • Anemia, low white blood cell count, and low platelet count may rarely happen.
    • Headache.
    • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
    • Loose stools. Yogurt or probiotics may help. You may get these products at health food stores or in some pharmacies.

    Contact a healthcare provider

    • If you think there was an overdose, call your local poison control center or ER right away.
    • Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Trouble breathing.
    • Change in thinking clearly and with logic.
    • Big change in balance.
    • Very bad headache.
    • Very upset stomach or throwing up.
    • Very loose stools, even after drug is stopped.
    • Any bruising or bleeding.
    • Feeling very tired or weak.
    • Sudden change in eyesight.
    • Any rash.
    • Health problem is not better or you are feeling worse.

    General Statements

    • If you have a very bad allergy, wear an allergy ID at all times.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep all drugs out of the reach of children and pets.
    • Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
    • In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada's Vigilance Program at 1-866-234-2345.
    • Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.

    Author information
    • Copyright © 1978-2010 Lexi-Comp Inc. All rights reserved.

    Copyright © 2011 Natural Standard (www.naturalstandard.com)


    The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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